The NUS/Harbin-led team identifies a domain-specific form of generative-AI hallucination: molecular candidates can receive strong predicted binding scores while violating basic chemistry or producing physically impossible atomic arrangements. Its DrugRPG framework incorporates chemical-foundation-model priors and differentiable physical constraints during molecule generation, reducing severe steric clashes by 65.4% relative to the reported state-of-the-art baseline and increasing by 28.6% the share of generated candidates meeting combined potency, stability, and synthetic-feasibility criteria.
The NUS/Harbin-led team identifies a domain-specific form of generative-AI hallucination: molecular candidates can receive strong predicted binding scores while violating basic chemistry or producing physically impossible atomic arrangements.
The broader implication is that reliable scientific AI may require enforceable domain laws rather than larger models or post-generation screening alone; however, these are computational benchmarks, not evidence that the generated compounds will survive laboratory or clinical validation.
Read the evidence behind this analysis. External links open in a new tab.
Nature
A review of evidence across cognitive science, education, medicine, and human-factors research finds that fully offloading mental work to AI can weaken the acquisition and retention of the specific skills people stop practicing. The authors distinguish that evidence from broader claims about declining intelligence: effects on foundational abilities such as attention and working memory remain uncertain, while AI used as a collaborator, tutor, or source of feedback can preserve or improve learning.
In a randomized field experiment across a chain of middle and high schools in Turkey, giving teachers a generative-AI support tool reduced students’ intrinsic motivation by 0.11 standard deviations. Average academic performance did not change, but students taught by lower-performing teachers experienced significant declines in both performance and confidence, showing that a tool that makes lesson preparation easier for teachers does not automatically improve the student experience.
The European Commission has issued operational guidance for Article 50 of the AI Act before its transparency obligations begin applying on August 2, 2026. Providers must disclose when people are interacting with systems such as chatbots, agents, or avatars and make generative outputs detectable through machine-readable marking; deployers must disclose emotion-recognition or biometric-categorization uses and clearly label deepfakes and certain AI-generated public-interest text when it lacks human review or editorial control.