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Cognition & learningGlobal+4 clusters01

Claude Opus 5 is more capable—and slightly more prone to factual hallucinations

Anthropic’s system card reports broad gains for Claude Opus 5 in agentic coding, computer use, long-horizon knowledge work, and scientific reasoning. It also documents a reliability tension: on one closed-book factuality benchmark, accuracy was 11% higher than Opus 4.8 while the hallucination rate was 6% higher. Anthropic found cases where the model confidently answered despite internal uncertainty, even as its automated alignment scores and prompt-injection robustness improved.

4 min
Work & marketsGlobal+3 clusters02

Liu et al., “Integrating chemical priors and physical laws to mitigate hallucinations in structure-based drug design”

The NUS/Harbin-led team identifies a domain-specific form of generative-AI hallucination: molecular candidates can receive strong predicted binding scores while violating basic chemistry or producing physically impossible atomic arrangements. Its DrugRPG framework incorporates chemical-foundation-model priors and differentiable physical constraints during molecule generation, reducing severe steric clashes by 65.4% relative to the reported state-of-the-art baseline and increasing by 28.6% the share of generated candidates meeting combined potency, stability, and synthetic-feasibility criteria.

2 min