University of Chicago and University of Wisconsin researchers randomized 180 hospitalized patients identified by a real-time machine-learning score as being at elevated risk of acute kidney injury. Triggering an early structured nephrology consultation did not significantly reduce peak creatinine changes, acute kidney injury, mortality, readmission, or other major outcomes; many specialist recommendations were not followed by the treating teams.
University of Chicago and University of Wisconsin researchers randomized 180 hospitalized patients identified by a real-time machine-learning score as being at elevated risk of acute kidney injury.
This provides unusually valuable negative evidence: an accurate risk signal did not improve outcomes when the surrounding clinical workflow could not reliably convert prediction into action.
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JAMA Network
A review of evidence across cognitive science, education, medicine, and human-factors research finds that fully offloading mental work to AI can weaken the acquisition and retention of the specific skills people stop practicing. The authors distinguish that evidence from broader claims about declining intelligence: effects on foundational abilities such as attention and working memory remain uncertain, while AI used as a collaborator, tutor, or source of feedback can preserve or improve learning.
In a randomized field experiment across a chain of middle and high schools in Turkey, giving teachers a generative-AI support tool reduced students’ intrinsic motivation by 0.11 standard deviations. Average academic performance did not change, but students taught by lower-performing teachers experienced significant declines in both performance and confidence, showing that a tool that makes lesson preparation easier for teachers does not automatically improve the student experience.
The NUS/Harbin-led team identifies a domain-specific form of generative-AI hallucination: molecular candidates can receive strong predicted binding scores while violating basic chemistry or producing physically impossible atomic arrangements. Its DrugRPG framework incorporates chemical-foundation-model priors and differentiable physical constraints during molecule generation, reducing severe steric clashes by 65.4% relative to the reported state-of-the-art baseline and increasing by 28.6% the share of generated candidates meeting combined potency, stability, and synthetic-feasibility criteria.